synthesis and determination of chronic and acute thermal and chemical pain activities of a new derivative of phencyclidine in rats

نویسندگان

abbas ahmadi department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran.

ramin hajikhani department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran.

leila barghi department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran.

farnaz mihandoust department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran.

چکیده

phencyclidine (1-(1-phenylcyclohexyl) piperidine, pcp, i) and ketamine (2-o-chlorophenyl-2-methylaminocyclohexan, ii) have shown analgesic effects. some of its derivatives were synthesized and their biological properties have been studied. in this study, a new derivative of pcp, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, pcp-och3-tetralyl, iii) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with ketamine and pcp. the results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following pcp-och3-tetralyl application in tail immersion test. however, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than pcp and pcp-och3-tetralyl exhibited almost similar analgesic effect.

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منابع مشابه

Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

متن کامل

Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

متن کامل

Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of...

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۲۰۱۰، شماره ۱۲، صفحات ۳۷۹-۳۸۵

کلمات کلیدی
[ ' p h e n c y c l i d i n e ' , ' k e t a m i n e ' , 1 , ' t e t r a l o n e d e r i v a t i v e s ' , ' t a i l i m m e r s i o n t e s t ' , ' f o r m a l i n t e s t ' , ' a c u t e a n d c h r o n i c p a i n ' ]

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