synthesis and determination of chronic and acute thermal and chemical pain activities of a new derivative of phencyclidine in rats
نویسندگان
چکیده
phencyclidine (1-(1-phenylcyclohexyl) piperidine, pcp, i) and ketamine (2-o-chlorophenyl-2-methylaminocyclohexan, ii) have shown analgesic effects. some of its derivatives were synthesized and their biological properties have been studied. in this study, a new derivative of pcp, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, pcp-och3-tetralyl, iii) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with ketamine and pcp. the results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following pcp-och3-tetralyl application in tail immersion test. however, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than pcp and pcp-och3-tetralyl exhibited almost similar analgesic effect.
منابع مشابه
Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...
متن کاملSynthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...
متن کاملSynthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۲۰۱۰، شماره ۱۲، صفحات ۳۷۹-۳۸۵
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